Mammary Stem Cells and Breast Cancer—Role of Notch Signalling

  title={Mammary Stem Cells and Breast Cancer—Role of Notch Signalling},
  author={Gillian Farnie and Robert B. Clarke},
  journal={Stem Cell Reviews},
Adult stem cells are found in numerous tissues of the body and play a role in tissue development, replacement and repair. Evidence shows that breast stem cells are multipotent and can self renew, which are key characteristics of stem cells, and a single cell enriched with cell surface markers has the ability to grow a fully functional mammary gland in vivo. Many groups have extrapolated the cancer stem cell hypothesis from the haematopoietic system to solid cancers, where using in vitro culture… CONTINUE READING
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Role of Notch and EGF receptor signaling pathways

  • G. Farnie, R. B. Clarke, +4 authors et al. . Novel cell culture technique for primary duc situ
  • Journal of the National Cancer Institute, 99 (8…
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