Mammalian tissues defective in nonsense-mediated mRNA decay display highly aberrant splicing patterns

@inproceedings{Weischenfeldt2011MammalianTD,
  title={Mammalian tissues defective in nonsense-mediated mRNA decay display highly aberrant splicing patterns},
  author={Joachim Weischenfeldt and Johannes Waage and Geng Tian and Jing Zhao and Inge Damgaard and Janus Schou Jakobsen and Karsten Kristiansen and Anders Krogh and Jun Wang and Bo T. Porse},
  booktitle={Genome Biology},
  year={2011}
}
Nonsense-mediated mRNA decay (NMD) affects the outcome of alternative splicing by degrading mRNA isoforms with premature termination codons. Splicing regulators constitute important NMD targets; however, the extent to which loss of NMD causes extensive deregulation of alternative splicing has not previously been assayed in a global, unbiased manner. Here, we combine mouse genetics and RNA-seq to provide the first in vivo analysis of the global impact of NMD on splicing patterns in two primary… CONTINUE READING
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