Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.

Abstract

Apoptosis signal-regulating kinase (ASK) 1 was recently identified as a mitogen-activated protein (MAP) kinase kinase kinase which activates the c-Jun N-terminal kinase (JNK) and p38 MAP kinase pathways and is required for tumor necrosis factor (TNF)-alpha-induced apoptosis; however, the mechanism regulating ASK1 activity is unknown. Through genetic… (More)

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Cite this paper

@article{Saitoh1998MammalianTI, title={Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.}, author={M. Saitoh and Hideki Nishitoh and M. Fujii and K. Takeda and Kei Tobiume and Y. Sawada and M.. Kawabata and Kazuhiro Miyazono and Hiroyuki Ichijo}, journal={The EMBO journal}, year={1998}, volume={17 9}, pages={2596-606} }