Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.

@article{Saitoh1998MammalianTI,
  title={Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.},
  author={Masao Saitoh and Hideki Nishitoh and Makiko Fujii and Kohsuke Takeda and Kei Tobiume and Yasuhiro Sawada and Masahiro Kawabata and Kohei Miyazono and Hidenori Ichijo},
  journal={The EMBO journal},
  year={1998},
  volume={17 9},
  pages={
          2596-606
        }
}
Apoptosis signal-regulating kinase (ASK) 1 was recently identified as a mitogen-activated protein (MAP) kinase kinase kinase which activates the c-Jun N-terminal kinase (JNK) and p38 MAP kinase pathways and is required for tumor necrosis factor (TNF)-alpha-induced apoptosis; however, the mechanism regulating ASK1 activity is unknown. Through genetic screening for ASK1-binding proteins, thioredoxin (Trx), a reduction/oxidation (redox)-regulatory protein thought to have anti-apoptotic effects… CONTINUE READING

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Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways

  • H Ichijo
  • Science
  • 1997

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