Mammalian target of rapamycin signalling modulates amino acid uptake by regulating transporter cell surface abundance in primary human trophoblast cells.

@article{Rosario2013MammalianTO,
  title={Mammalian target of rapamycin signalling modulates amino acid uptake by regulating transporter cell surface abundance in primary human trophoblast cells.},
  author={Fredrick J Rosario and Yoshikatsu Kanai and Theresa L. Powell and T. Jansson},
  journal={The Journal of physiology},
  year={2013},
  volume={591 3},
  pages={
          609-25
        }
}
Abnormal fetal growth increases the risk for perinatal complications and predisposes for the development of obesity, diabetes and cardiovascular disease later in life. Emerging evidence suggests that changes in placental amino acid transport directly contribute to altered fetal growth. However, the molecular mechanisms regulating placental amino acid transport are largely unknown. Here we combined small interfering (si) RNA-mediated silencing approaches with protein expression/localization and… CONTINUE READING
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