Mammalian target of rapamycin signaling in cardiac physiology and disease.

  title={Mammalian target of rapamycin signaling in cardiac physiology and disease.},
  author={Sebastiano Sciarretta and Massimo Volpe and Junichi Sadoshima},
  journal={Circulation research},
  volume={114 3},
The protein kinase mammalian or mechanistic target of rapamycin (mTOR) is an atypical serine/threonine kinase that exerts its main cellular functions by interacting with specific adaptor proteins to form 2 different multiprotein complexes, mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). mTORC1 regulates protein synthesis, cell growth and proliferation, autophagy, cell metabolism, and stress responses, whereas mTORC2 seems to regulate cell survival and polarity. The mTOR pathway plays a key… CONTINUE READING
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