Mammalian target of rapamycin pathway blockade slows progression of diabetic kidney disease in rats.

@article{Lloberas2006MammalianTO,
  title={Mammalian target of rapamycin pathway blockade slows progression of diabetic kidney disease in rats.},
  author={N{\'u}ria Lloberas and Josep Mar{\'i}a Cruzado and Marcella Franquesa and Immaculada Herrero-Fresneda and Juan Torras and Gabriela Alperovich and In{\'e}s Rama and August Vidal and Josep Mar{\'i}a Grinyo},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2006},
  volume={17 5},
  pages={1395-404}
}
Recent data suggest that the phosphatidylinositol 3-kinase (PI3-K)/Akt/mammalian target of rapamycin (mTOR) pathway is important in diabetic nephropathy. The effect of mTOR blockade by sirolimus (SRL) in diabetic kidney disease in rats was investigated. Diabetes was induced by streptozotocin in male Sprague-Dawley rats. Sixteen weeks later, diabetic animals were divided into the following groups: diabetes (D; n = 8), diabetes + SRL at 1 mg/kg per d, SRL trough level 2.3 +/- 0.25 ng/ml (D+SRL; n… CONTINUE READING
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Non-immunosuppressives levels of rapamycin inhibit mesangial cell proliferation and extracellular matrix production [Abstract

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