Mammalian target of rapamycin integrates diverse inputs to guide the outcome of antigen recognition in T cells.

@article{Waickman2012MammalianTO,
  title={Mammalian target of rapamycin integrates diverse inputs to guide the outcome of antigen recognition in T cells.},
  author={Adam T. Waickman and Jonathan D. Powell},
  journal={Journal of immunology},
  year={2012},
  volume={188 10},
  pages={4721-9}
}
T cells must integrate a diverse array of intrinsic and extrinsic signals upon Ag recognition. Although these signals have canonically been categorized into three distinct events--Signal 1 (TCR engagement), Signal 2 (costimulation or inhibition), and Signal 3 (cytokine exposure)--it is now appreciated that many other environmental cues also dictate the outcome of T cell activation. These include nutrient availability, the presence of growth factors and stress signals, as well as chemokine… CONTINUE READING