Mammalian target of rapamycin inhibitors are associated with lower rates of hepatocellular carcinoma recurrence after liver transplantation: a systematic review.

@article{Cholongitas2014MammalianTO,
  title={Mammalian target of rapamycin inhibitors are associated with lower rates of hepatocellular carcinoma recurrence after liver transplantation: a systematic review.},
  author={Evangelos Cholongitas and Chrysanthi Mamou and Kryssia Isabel Rodr{\'i}guez-Castro and Patrizia Burra},
  journal={Transplant international : official journal of the European Society for Organ Transplantation},
  year={2014},
  volume={27 10},
  pages={
          1039-49
        }
}
  • Evangelos Cholongitas, Chrysanthi Mamou, +1 author Patrizia Burra
  • Published in
    Transplant international…
    2014
  • Medicine
  • Calcineurin inhibitors (CNIs) have been associated in a dose-dependent fashion with an increased risk of post-transplant hepatocellular carcinoma (HCC) recurrence. The mammalian target of rapamycin inhibitors (mTORi) (sirolimus/everolimus) might represent an alternative immunosuppressive regimen with antineoplastic effect. In the present systematic review, the association between mTORi and HCC recurrence after liver transplantation (LT) was evaluated and compared against that of CNIs-treated… CONTINUE READING

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