Mammalian target of rapamycin inhibitors, temsirolimus and torin 1, attenuate stemness-associated properties and expression of mesenchymal markers promoted by phorbol-myristate-acetate and oncostatin-M in glioblastoma cells.

@article{Chandrika2017MammalianTO,
  title={Mammalian target of rapamycin inhibitors, temsirolimus and torin 1, attenuate stemness-associated properties and expression of mesenchymal markers promoted by phorbol-myristate-acetate and oncostatin-M in glioblastoma cells.},
  author={Goparaju Chandrika and Kumar Natesh and Deepak Ranade and Ashish P. Chugh and Padma Shastry},
  journal={Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine},
  year={2017},
  volume={39 3},
  pages={1010428317695921}
}
The phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling pathway is crucial for tumor survival, proliferation, and progression, making it an attractive target for therapeutic intervention. In glioblastoma, activated mammalian target of rapamycin promotes invasive phenotype and correlates with poor patient survival. A wide range of mammalian target of rapamycin inhibitors are currently being evaluated for cytotoxicity and anti-proliferative activity in various tumor types… CONTINUE READING