Mammalian target of rapamycin controls dendritic cell development downstream of Flt3 ligand signaling.


Dendritic cells (DCs) comprise distinct functional subsets including CD8⁻ and CD8(+) classical DCs (cDCs) and interferon-secreting plasmacytoid DCs (pDCs). The cytokine Flt3 ligand (Flt3L) controls the development of DCs and is particularly important for the pDC and CD8(+) cDC and their CD103(+) tissue counterparts. We report that mammalian target of… (More)
DOI: 10.1016/j.immuni.2010.09.012

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