Mammalian target of rapamycin complex 2 regulates inflammatory response to stress

Abstract

To explore the role of mammalian target of rapamycin 2 (mTORC2) in the activation of inflammatory and oxidative responses in rodent models of acute injury and metabolic stress. The impact of nephrilin, an inhibitor of mTORC2 complex, was assessed in three CD-1 mouse models of acute xenobiotic stress and in a hypertensive Dahl rat model of metabolic stress… (More)
DOI: 10.1007/s00011-012-0542-7

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