Mammalian target of rapamycin complex 1 (mTORC1) and 2 (mTORC2) control the dendritic arbor morphology of hippocampal neurons.

@article{Urbanska2012MammalianTO,
  title={Mammalian target of rapamycin complex 1 (mTORC1) and 2 (mTORC2) control the dendritic arbor morphology of hippocampal neurons.},
  author={Malgorzata Urbanska and Agata Gozdz and Lukasz J. Swiech and Jacek Jaworski},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 36},
  pages={30240-56}
}
Dendrites are the main site of information input into neurons. Their development is a multistep process controlled by mammalian target of rapamycin (mTOR) among other proteins. mTOR is a serine/threonine protein kinase that forms two functionally distinct complexes in mammalian cells: mTORC1 and mTORC2. However, the one that contributes to mammalian neuron development remains unknown. This work used short hairpin RNA against Raptor and Rictor, unique components of mTORC1 and mTORC2… CONTINUE READING