Mammalian target of rapamycin as a therapeutic target in leukemia.

  title={Mammalian target of rapamycin as a therapeutic target in leukemia.},
  author={Francis J Giles and Maher Albitar},
  journal={Current molecular medicine},
  volume={5 7},
Reflecting its critical role in integrating cell growth and division with the cellular nutritional environment, the mammalian target of rapamycin *(mTOR) is a highly conserved downstream effector of the phosphatidylinositol 3-kinase (PI3K)/Akt (protein kinase B) signaling pathway. mTOR activates both the 40S ribosomal protein S6 kinase (p70s6k) and the eukaryotic initiation factor 4E-binding protein-1. As a consequence of inhibiting its downstream messengers, mTOR inhibitors prevent cyclin… CONTINUE READING


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