Mammalian target of rapamycin and the kidney. II. Pathophysiology and therapeutic implications.

@article{Lieberthal2012MammalianTO,
  title={Mammalian target of rapamycin and the kidney. II. Pathophysiology and therapeutic implications.},
  author={Wilfred Lieberthal and Jerrold S. Levine},
  journal={American journal of physiology. Renal physiology},
  year={2012},
  volume={303 2},
  pages={
          F180-91
        }
}
The mTOR pathway plays an important role in a number of common renal diseases, including acute kidney injury (AKI), diabetic nephropathy (DN), and polycystic kidney diseases (PKD). The activity of mTOR complex 1 (mTORC1) is necessary for renal regeneration and repair after AKI, and inhibition of mTORC1 by rapamycin has been shown to delay recovery from ischemic AKI in animal studies, and to prolong delayed graft function in humans who have received a kidney transplant. For this reason… CONTINUE READING
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