Mammalian target of rapamycin and S6 kinase 1 positively regulate 6-thioguanine-induced autophagy.

@article{Zeng2008MammalianTO,
  title={Mammalian target of rapamycin and S6 kinase 1 positively regulate 6-thioguanine-induced autophagy.},
  author={Xuehuo Zeng and Timothy J. Kinsella},
  journal={Cancer research},
  year={2008},
  volume={68 7},
  pages={2384-90}
}
DNA mismatch repair (MMR) ensures the fidelity of DNA replication and is required for activation of cell cycle arrest and apoptosis in response to certain classes of DNA damage. We recently reported that MMR is also implicated in initiation of an autophagic response after MMR processing of 6-thioguanine (6-TG). It is now generally believed that autophagy is negatively controlled by mammalian target of rapamycin (mTOR) activity. To determine whether mTOR is involved in 6-TG-induced autophagy, we… CONTINUE READING