Mammalian target of rapamycin (mTOR) activation increases axonal growth capacity of injured peripheral nerves.

@article{Abe2010MammalianTO,
  title={Mammalian target of rapamycin (mTOR) activation increases axonal growth capacity of injured peripheral nerves.},
  author={Namiko Abe and Steven H Borson and Michael J Gambello and Fan Wang and Valeria Cavalli},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 36},
  pages={28034-43}
}
Unlike neurons in the central nervous system (CNS), injured neurons in the peripheral nervous system (PNS) can regenerate their axons and reinnervate their targets. However, functional recovery in the PNS often remains suboptimal, especially in cases of severe damage. The lack of regenerative ability of CNS neurons has been linked to down-regulation of the mTOR (mammalian target of rapamycin) pathway. We report here that PNS dorsal root ganglial neurons (DRGs) activate mTOR following damage and… CONTINUE READING

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