Mammalian target of rapamycin: immunosuppressive drugs uncover a novel pathway of cytokine receptor signaling.

@article{Abraham1998MammalianTO,
  title={Mammalian target of rapamycin: immunosuppressive drugs uncover a novel pathway of cytokine receptor signaling.},
  author={Robert T. Abraham},
  journal={Current opinion in immunology},
  year={1998},
  volume={10 3},
  pages={330-6}
}
Recent findings have significantly advanced our understanding of the mechanism by which the potent immunosuppressive drug rapamycin inhibits cytokine-dependent lymphocyte proliferation. The protein targeted by the immunophilin-rapamycin complex is a member of a newly defined family of phosphoinositide-3-kinase-related kinases. The rapamycin target protein functions as a protein kinase in a signal transduction pathway that regulates the synthesis of proteins required for cell-cycle progression… CONTINUE READING

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