Mammalian stress granules represent sites of accumulation of stalled translation initiation complexes.

@article{Kimball2003MammalianSG,
  title={Mammalian stress granules represent sites of accumulation of stalled translation initiation complexes.},
  author={Scot R. Kimball and Rick L Horetsky and David S{\'a}nchez de Ron and Leonard S. Jefferson and Heather P Harding},
  journal={American journal of physiology. Cell physiology},
  year={2003},
  volume={284 2},
  pages={
          C273-84
        }
}
  • Scot R. Kimball, Rick L Horetsky, +2 authors Heather P Harding
  • Published in
    American journal of…
    2003
  • Medicine, Biology
  • In eukaryotic cells subjected to environmental stress, untranslated mRNA accumulates in discrete cytoplasmic foci that have been termed stress granules. Recent studies have shown that in addition to mRNA, stress granules also contain 40S ribosomal subunits and various translation initiation factors, including the mRNA binding proteins eIF4E and eIF4G. However, eIF2, the protein that transfers initiator methionyl-tRNA(i) (Met-tRNA(i)) to the 40S ribosomal subunit, has not been detected in stress… CONTINUE READING

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    References

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    Dynamic Shuttling of Tia-1 Accompanies the Recruitment of mRNA to Mammalian Stress Granules

    VIEW 5 EXCERPTS
    HIGHLY INFLUENTIAL

    Stressful initiations.

    VIEW 2 EXCERPTS