Mammalian sphingosine kinase (SphK) isoenzymes and isoform expression: challenges for SphK as an oncotarget

@inproceedings{Hatoum2017MammalianSK,
  title={Mammalian sphingosine kinase (SphK) isoenzymes and isoform expression: challenges for SphK as an oncotarget},
  author={Diana Hatoum and Nahal Haddadi and Yiguang Lin and Najah Therese Nassif and Eileen M McGowan},
  booktitle={Oncotarget},
  year={2017}
}
The various sphingosine kinase (SphK) isoenzymes (isozymes) and isoforms, key players in normal cellular physiology, are strongly implicated in cancer and other diseases. Mutations in SphKs, that may justify abnormal physiological function, have not been recorded. Nonetheless, there is a large and growing body of evidence demonstrating the contribution of gain or loss of function and the imbalance in the SphK/S1P rheostat to a plethora of pathological conditions including cancer, diabetes and… CONTINUE READING

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