Mammalian sexual differentiation: lessons from the spotted hyena

  title={Mammalian sexual differentiation: lessons from the spotted hyena},
  author={S. Glickman and G. Cunha and C. Drea and A. J. Conley and N. Place},
  journal={Trends in Endocrinology & Metabolism},
  • S. Glickman, G. Cunha, +2 authors N. Place
  • Published 2006
  • Medicine, Biology
  • Trends in Endocrinology & Metabolism
  • Female spotted hyenas (Crocuta crocuta) are the only female mammals that lack an external vaginal opening. Mating and birth take place through a urogenital canal that exits at the tip of a hypertrophied clitoris. This 'masculine' phenotype spurred a search for an alternate source of fetal androgens. Although androstenedione from the maternal ovary is readily metabolized to testosterone by the hyena placenta, formation of the penile clitoris and scrotum appear to be largely androgen independent… CONTINUE READING
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