Mammalian recombination-repair genes XRCC2 and XRCC3 promote correct chromosome segregation

  title={Mammalian recombination-repair genes XRCC2 and XRCC3 promote correct chromosome segregation},
  author={Carol S. Griffin and Paul J. Simpson and Caroline R. Wilson and John Thacker},
  journal={Nature Cell Biology},
Growth and development are dependent on the faithful duplication of cells. Duplication requires accurate genome replication, the repair of any DNA damage, and the precise segregation of chromosomes at mitosis; molecular checkpoints ensure the proper progression and fidelity of each stage. Loss of any of these highly conserved functions may result in genetic instability and proneness to cancer. Here we show that highly significant increases in chromosome missegregation occur in cell lines… CONTINUE READING
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Correspondence and requests for materials should be addressed to J.T. brief communications NATURE CELL BIOLOGY VOL 2 OCTOBER 2000

  • Bishop, K D.
  • J. Biol
  • 1999

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