Mammalian polo-like kinase 1-dependent regulation of the PBIP1-CENP-Q complex at kinetochores.

@article{Kang2011MammalianPK,
  title={Mammalian polo-like kinase 1-dependent regulation of the PBIP1-CENP-Q complex at kinetochores.},
  author={Young Hwi Kang and Chi Hoon Park and Tae-Sung Kim and Nak-Kyun Soung and Jeong Kyu Bang and Bo Yeon Kim and Jung-Eun · Lee Park and Kyung S Lee},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 22},
  pages={19744-57}
}
Mammalian polo-like kinase 1 (Plk1) plays a pivotal role during M-phase progression. Plk1 localizes to specific subcellular structures through the targeting activity of the C-terminal polo-box domain (PBD). Disruption of the PBD function results in improper bipolar spindle formation, chromosome missegregation, and cytokinesis defect that ultimately lead to the generation of aneuploidy. It has been shown that Plk1 recruits itself to centromeres by phosphorylating and binding to a centromere… CONTINUE READING