Mammalian orthologues of a yeast regulator of nonsense transcript stability.

Abstract

All eukaryotes that have been studied to date possess the ability to detect and degrade transcripts that contain a premature signal for the termination of translation. This process of nonsense-mediated RNA decay has been most comprehensively studied in the yeast Saccharomyces cerevisiae where at least three trans-acting factors (Upf1p through Upf3P) are… (More)

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@article{Perlick1996MammalianOO, title={Mammalian orthologues of a yeast regulator of nonsense transcript stability.}, author={H A Perlick and Susan M Medghalchi and Fred Spencer and Raymond J. Kendzior and Harry C Dietz}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1996}, volume={93 20}, pages={10928-32} }