Mammalian nuclei become licensed for DNA replication during late telophase.

  title={Mammalian nuclei become licensed for DNA replication during late telophase.},
  author={Daniela S. Dimitrova and Tatyana A. Prokhorova and J Julian Blow and I. T. Todorov and David M. Gilbert},
  journal={Journal of cell science},
  volume={115 Pt 1},
Mcm 2-7 are essential replication proteins that bind to chromatin in mammalian nuclei during late telophase. Here, we have investigated the relationship between Mcm binding, licensing of chromatin for replication, and specification of the dihydrofolate reductase (DHFR) replication origin. Approximately 20% of total Mcm3 protein was bound to chromatin in Chinese hamster ovary (CHO) cells during telophase, while an additional 25% bound gradually and cumulatively throughout G1-phase. To… CONTINUE READING
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