Mammalian nicotinic acetylcholine receptors: from structure to function.

@article{Albuquerque2009MammalianNA,
  title={Mammalian nicotinic acetylcholine receptors: from structure to function.},
  author={Edson X. Albuquerque and E. Rodrigues Pereira and Manickavasagom Alkondon and Scott Warren Rogers},
  journal={Physiological reviews},
  year={2009},
  volume={89 1},
  pages={73-120}
}
The classical studies of nicotine by Langley at the turn of the 20th century introduced the concept of a "receptive substance," from which the idea of a "receptor" came to light. Subsequent studies aided by the Torpedo electric organ, a rich source of muscle-type nicotinic receptors (nAChRs), and the discovery of alpha-bungarotoxin, a snake toxin that binds pseudo-irreversibly to the muscle nAChR, resulted in the muscle nAChR being the best characterized ligand-gated ion channel hitherto. With… CONTINUE READING
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Despite these numerous developments , our understanding of the contributions of specific neuronal nAChR subtypes to the many facets of physiology throughout the body remains in its infancy .
Despite these numerous developments , our understanding of the contributions of specific neuronal nAChR subtypes to the many facets of physiology throughout the body remains in its infancy .
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