Mammalian neural and endocrine pro-protein and pro-hormone convertases belonging to the subtilisin family of serine proteinases.

@article{Seidah1991MammalianNA,
  title={Mammalian neural and endocrine pro-protein and pro-hormone convertases belonging to the subtilisin family of serine proteinases.},
  author={Nabil G Seidah and Robert Day and Mieczyslaw Marcinkiewicz and Suzanne Benjannet and Michel Chr{\'e}tien},
  journal={Enzyme},
  year={1991},
  volume={45 5-6},
  pages={271-84}
}
Conversion of pro-hormones and precursor proteins into biologically active peptides and proteins involves the concerted action of a number of convertases and post-translation modification enzymes. The identification of the yeast convertase kexin as a prototype processing enzyme led to the discovery of the mammalian convertase designated furin, PC1 and PC2. Whereas furin is ubiquitously expressed, PC1 and PC2 are found only in endocrine and neural tissues and cell lines. In man and mouse, the… CONTINUE READING

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