Mammalian molybdo-flavoenzymes, an expanding family of proteins: structure, genetics, regulation, function and pathophysiology.

@article{Garattini2003MammalianMA,
  title={Mammalian molybdo-flavoenzymes, an expanding family of proteins: structure, genetics, regulation, function and pathophysiology.},
  author={Enrico Garattini and Ralf R Mendel and Maria Jo{\~a}o Rom{\~a}o and Richard Wright and Mineko Terao},
  journal={The Biochemical journal},
  year={2003},
  volume={372 Pt 1},
  pages={
          15-32
        }
}
The molybdo-flavoenzymes are structurally related proteins that require a molybdopterin cofactor and FAD for their catalytic activity. In mammals, four enzymes are known: xanthine oxidoreductase, aldehyde oxidase and two recently described mouse proteins known as aldehyde oxidase homologue 1 and aldehyde oxidase homologue 2. The present review article summarizes current knowledge on the structure, enzymology, genetics, regulation and pathophysiology of mammalian molybdo-flavoenzymes. Molybdo… Expand
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