Mammalian mitochondrial and microsomal cytochromes b(5) exhibit divergent structural and biophysical characteristics.

@article{Altuve2004MammalianMA,
  title={Mammalian mitochondrial and microsomal cytochromes b(5) exhibit divergent structural and biophysical characteristics.},
  author={Adriana Altuve and Lijun Wang and David R. Benson and Mario Rivera},
  journal={Biochemical and biophysical research communications},
  year={2004},
  volume={314 2},
  pages={602-9}
}
The only outer mitochondrial membrane cytochrome b(5) examined to date, from rat (rOM b(5)), exhibits greater stability than known mammalian microsomal (Mc) isoforms, as well as a much higher kinetic barrier for hemin dissociation and a more negative reduction potential. A BlastP search of available databases using the protein sequence of rOM b(5) as template revealed entries for analogous proteins from human (hOM b(5)) and mouse (mOM b(5)). We prepared a synthetic gene coding for the heme… CONTINUE READING

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