Mammalian microRNAs: experimental evaluation of novel and previously annotated genes.

@article{Chiang2010MammalianME,
  title={Mammalian microRNAs: experimental evaluation of novel and previously annotated genes.},
  author={H. Rosaria Chiang and Lori W. Schoenfeld and J. G. Ruby and Vincent C. Auyeung and Noah Spies and Daehyun Baek and Wendy K. Johnston and Carsten Russ and Shujun Luo and Joshua Babiarz and Robert Blelloch and Gary P. Schroth and Chad Nusbaum and David P. Bartel},
  journal={Genes & development},
  year={2010},
  volume={24 10},
  pages={992-1009}
}
MicroRNAs (miRNAs) are small regulatory RNAs that derive from distinctive hairpin transcripts. To learn more about the miRNAs of mammals, we sequenced 60 million small RNAs from mouse brain, ovary, testes, embryonic stem cells, three embryonic stages, and whole newborns. Analysis of these sequences confirmed 398 annotated miRNA genes and identified 108 novel miRNA genes. More than 150 previously annotated miRNAs and hundreds of candidates failed to yield sequenced RNAs with miRNA-like features… CONTINUE READING
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