Mammalian macroautophagy at a glance.

  title={Mammalian macroautophagy at a glance.},
  author={Brinda Ravikumar and Marie Futter and Luca Jahreiss and Viktor I. Korolchuk and M. W. K. Lichtenberg and Shouqing Luo and Dunecan C O Massey and Fiona Mhairi Menzies and Usha Narayanan and Maurizio Renna and Mar{\'i}a Jim{\'e}nez-S{\'a}nchez and Sovan Sarkar and Benjamin R. Underwood and Ashley R. Winslow and David C Rubinsztein},
  journal={Journal of cell science},
  volume={122 Pt 11},
Autophagy refers to a set of non-specific bulk degradation processes in which cells deliver cytoplasmic substrates for lysosomal degradation. Types of autophagy include macroautophagy, chaperone-mediated autophagy and microautophagy. Chaperone-mediated autophagy is selective for specific cytosolic proteins that contain a pentapeptide motif. This motif is recognised by the chaperone heat shock cognate 70 (Hsc70), which transfers protein substrates to the lysosomal membrane where, through binding… CONTINUE READING