Mammalian intermediate-term memory: New findings in neonate rat

  title={Mammalian intermediate-term memory: New findings in neonate rat},
  author={Matthew T. Grimes and Melissa Smith and XuQin Li and Andrea Darby-King and Carolyn W. Harley and John H. McLean},
  journal={Neurobiology of Learning and Memory},
PKA increases in the olfactory bulb act as unconditioned stimuli and provide evidence for parallel memory systems: pairing odor with increased PKA creates intermediate- and long-term, but not short-term, memories.
It is suggested that increased bulbar PKA is necessary and sufficient for the induction of intermediate-term and long-term odor-preference memory, and suggest that PKA activation levels also modulate memory duration.
The molecular signaling of the unconditioned stimulus in rat pup long-term odor preference memory: support for parallel, not serial, memory models
The present thesis sets out to identify the underlying molecular mechanisms that produce 24 h neonatal odor preference memory with specific focus on the US of cAMP signaling, demonstrating the three characteristics of invertebrate memory in mammalian memory.
Molecular correlates of multiday memory in an appetitive conditioning model: insights into mediators of memory extension
These experiments support CREB as a possible initiator in mediating downstream events leading to the changes in synaptic plasticity that accompany extension of long-term memory.
Mechanisms underlying early odor preference learning in rats.
Learning-induced mRNA alterations in olfactory bulb mitral cells in neonatal rats.
The small number of gene changes identified in the mitral cell input/output link for 24 h memory will facilitate investigation of the nature, and reversibility, of changes supporting temporally restricted long-term memory.
NMDA receptors in mouse anterior piriform cortex initialize early odor preference learning and L-type calcium channels engage for long-term memory
The results suggest that NMDARs mediate stimulus-specific encoding of odor memory while LTCCs Mediate intracellular signaling leading to long-term memory.
Epac activation initiates associative odor preference memories in the rat pup.
The results suggest that Epac and PKA play parallel and independent, as well as likely synergistic, roles in creating cAMP-dependent associative memory in rat pups, and implicate a novel ERK-independent pathway in the mediation of STM by Epac.
An investigation into mRNA expression in the rat pup olfactory bulb after odor preference learning.
Several of the genes confirmed as changing with learning are known to be involved in plasticity related activities, but were not previously associated with olfactory learning and memory formation.
Unlearning: NMDA Receptor-Mediated Metaplasticity in the Anterior Piriform Cortex Following Early Odor Preference Training in Rats
Here we demonstrate metaplastic effect of a change in NMDA receptor (NMDAR) number in the anterior piriform cortex (aPC) in rat induced by a 10 min pairing of peppermint odor + stroking, which


Intermediate-Term Memory for Site-Specific Sensitization in Aplysia Is Maintained by Persistent Activation of Protein Kinase C
It is shown that a single tail shock can also induce ITM that is expressed selectively at the trained site (site-specific ITM), which is phenotypically similar to the form of ITM induced by repeated trials, but the mechanisms by which site- specific ITM is induced and maintained are distinct.
A single time‐window for protein synthesis‐dependent long‐term memory formation after one‐trial appetitive conditioning
It is unusual to find only one period of protein synthesis‐dependence in detailed time‐course studies of LTM, and this suggests that the consolidation processes involving protein synthesis are relatively rapid in one‐trial appetitive conditioning and complete within 1 h of training.
Intermediate and long-term memories of associative learning are differentially affected by transcription versus translation blockers inLymnaea
In Lymnaea, following associative learning, both ITM and LTM are dependent on new protein synthesis, whereas ITM appears to be dependent on protein synthesis from preexisting transcription factors, whilst LTM is dependent onprotein synthesis from new transcription messages.
Memory Consolidation of Auditory Pavlovian Fear Conditioning Requires Protein Synthesis and Protein Kinase A in the Amygdala
It is suggested that the LA is essential for memory consolidation of auditory fear conditioning and that this process is PKA and protein-synthesis dependent.
Requirement of Translation But Not Transcription for the Maintenance of Long-Term Depression in the CA1 Region of Freely Moving Rats
Data suggest that LTD in the CA1 region in vivo is protein synthesis-dependent, and persistent LTD can be established through the translation of existing mRNA, whereas de novo mRNA transcription does not appear to be necessary.
Molecular Pharmacological Dissection of Short- and Long-Term Memory
STM is separate from, and parallel to the first hours of processing of, LTM of that task, and the only way to solve this dilemma is to find out at least one treatment that blocks STM while keeping LTM intact for the same task in the same animal.
Norepinephrine and learning-induced plasticity in infant rat olfactory system
Norepinephrine is sufficient and may be necessary for the acquisition of both learned olfactory behavior and Olfactory bulb responses in neonatal rat pups.