Mammalian homologues of yeast vacuolar protein sorting (vps) genes implicated in Golgi-to-lysosome trafficking.

@article{Pevsner1996MammalianHO,
  title={Mammalian homologues of yeast vacuolar protein sorting (vps) genes implicated in Golgi-to-lysosome trafficking.},
  author={Jonathan Pevsner and Shu Ching Hsu and Peter S. Hyde and Richard H. Scheller},
  journal={Gene},
  year={1996},
  volume={183 1-2},
  pages={7-14}
}
Sec1p, Vps33p, Vps45p and Sly1p constitute a family of proteins implicated in vesicle trafficking at distinct stages of the yeast secretory pathway. Several mammalian homologues of Sec1p have been described, including n-sec1 which has been implicated in the regulation of synaptic vesicle docking at the nerve terminal. We have characterized cDNA clones encoding three additional mammalian homologues belonging to this family: r-vps33a and r-vps33b from rat, which are 30 and 26% identical to yeast… CONTINUE READING

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