Mammalian homologues of C. elegans PAR-1 are asymmetrically localized in epithelial cells and may influence their polarity

@article{Boehm1997MammalianHO,
  title={Mammalian homologues of C. elegans PAR-1 are asymmetrically localized in epithelial cells and may influence their polarity},
  author={Hans - J. Boehm and V Brinkmann and Marek Drab and Annemarie Henske and Teymuras V Kurzchalia},
  journal={Current Biology},
  year={1997},
  volume={7},
  pages={603-606}
}
The establishment of polarity in the embryo is fundamental for the correct development of an organism [1]. The first cleavage of the Caenorhabditis elegans embryo is asymmetric with certain cytoplasmic components being distributed unequally between the daughter cells [2-4]. Using a genetic screen, Kemphues and co-workers have identified six par genes (partition-defective) [5,6], which are involved in the process of asymmetric division. One of these genes encodes a highly conserved protein, PAR… CONTINUE READING

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