Mammalian hepatocyte differentiation requires the transcription factor HNF-4alpha.

@article{Li2000MammalianHD,
  title={Mammalian hepatocyte differentiation requires the transcription factor HNF-4alpha.},
  author={Jin Li and Guang Ning and S A Duncan},
  journal={Genes & development},
  year={2000},
  volume={14 4},
  pages={464-74}
}
HNF-4alpha is a transcription factor of the nuclear hormone receptor family that is expressed in the hepatic diverticulum at the onset of liver development. Mouse embryos lacking HNF-4alpha fail to complete gastrulation due to dysfunction of the visceral endoderm. This early embryonic lethality has so far prevented any analyses of the contribution of HNF-4alpha toward liver development and hepatocyte differentiation. However, we have shown that complementation of HNF-4alpha(-/-) embryos with a… CONTINUE READING
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Inactivation of the winged helix transcription factor HNF 3 a affects glucose homeostasis and islet glucagon gene expression in vivo

  • I. Tzameli, M. Hadzopoulou-Cladaras
  • Genes & Dev .
  • 1999

Mutation in the HNF - 4 alpha gene affects insulin secretion and triglyceride metabolism

  • D. Van Antwerp
  • Diabetes
  • 1999

Scat - ter factor / hepatocyte growth factor is essential for liver development

  • S. Kuwajima, S. A. Duncan, M. Stoffel
  • Nature
  • 1999

Disruption of the HNF - 4 gene , expressed in visceral endoderm , leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos

  • C. E. McPherson, P. Bossard, +5 authors K. S. Zaret
  • Genes & Dev .
  • 1998

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