Mammalian hepatocyte differentiation requires the transcription factor HNF-4alpha.

  title={Mammalian hepatocyte differentiation requires the transcription factor HNF-4alpha.},
  author={Jin Li and Guang Ning and S A Duncan},
  journal={Genes & development},
  volume={14 4},
HNF-4alpha is a transcription factor of the nuclear hormone receptor family that is expressed in the hepatic diverticulum at the onset of liver development. Mouse embryos lacking HNF-4alpha fail to complete gastrulation due to dysfunction of the visceral endoderm. This early embryonic lethality has so far prevented any analyses of the contribution of HNF-4alpha toward liver development and hepatocyte differentiation. However, we have shown that complementation of HNF-4alpha(-/-) embryos with a… CONTINUE READING
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