Mammalian heparanase: involvement in cancer metastasis, angiogenesis and normal development.

@article{Vlodavsky2002MammalianHI,
  title={Mammalian heparanase: involvement in cancer metastasis, angiogenesis and normal development.},
  author={Israel Vlodavsky and Orit Goldshmidt and Eyal Zcharia and Ruth Atzmon and Zehava Rangini-Guatta and Michael Elkin and Tamar Peretz and Yael Friedmann},
  journal={Seminars in cancer biology},
  year={2002},
  volume={12 2},
  pages={121-9}
}
Cleavage of heparan sulphate proteoglycans (HSPGs) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular microenvironment. Heparanase, degrading heparan sulphate (HS) at specific intrachain sites, is synthesized as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. The heparanase enzyme is… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 77 extracted citations

Similar Papers

Loading similar papers…