Mammalian genes induce partially reprogrammed pluripotent stem cells in non-mammalian vertebrate and invertebrate species

@inproceedings{Rossell2013MammalianGI,
  title={Mammalian genes induce partially reprogrammed pluripotent stem cells in non-mammalian vertebrate and invertebrate species},
  author={Ricardo Antonio Rossell{\'o} and Chun-chun Chen and Rui Dai and Jason T Howard and Ute Hochgeschwender and Erich D. Jarvis},
  booktitle={eLife},
  year={2013}
}
Cells are fundamental units of life, but little is known about evolution of cell states. Induced pluripotent stem cells (iPSCs) are once differentiated cells that have been re-programmed to an embryonic stem cell-like state, providing a powerful platform for biology and medicine. However, they have been limited to a few mammalian species. Here we found that a set of four mammalian transcription factor genes used to generate iPSCs in mouse and humans can induce a partially reprogrammed… CONTINUE READING

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