Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering.

  title={Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering.},
  author={Han Li and Alexei V. Korennykh and Shannon L Behrman and Peter J. Walter},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={107 37},
Accumulation of misfolded proteins in the endoplasmic reticulum (ER) triggers the unfolded protein response (UPR), an intracellular signaling pathway that adjusts the protein folding capacity of the ER according to need. If homeostasis in the ER protein folding environment cannot be reestablished, cells commit to apoptosis. The ER-resident transmembrane kinase-endoribonuclease inositol-requiring enzyme 1 (IRE1) is the best characterized UPR signal transduction molecule. In yeast, Ire1… CONTINUE READING
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