Mammalian egg activation: from Ca2+ spiking to cell cycle progression.

@article{Jones2005MammalianEA,
  title={Mammalian egg activation: from Ca2+ spiking to cell cycle progression.},
  author={Keith T Jones},
  journal={Reproduction},
  year={2005},
  volume={130 6},
  pages={813-23}
}
Mammalian eggs arrest at metaphase of the second meiotic division (MetII). Sperm break this arrest by inducing a series of Ca(2+) spikes that last for several hours. During this time cell cycle resumption is induced, sister chromatids undergo anaphase and the second polar body is extruded. This is followed by decondensation of the chromatin and the formation of pronuclei. Ca(2+) spiking is both the necessary and solely sufficient sperm signal to induce full egg activation. How MetII arrest is… CONTINUE READING

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