Mammalian circadian clock system: Molecular mechanisms for pharmaceutical and medical sciences.

@article{Okamura2010MammalianCC,
  title={Mammalian circadian clock system: Molecular mechanisms for pharmaceutical and medical sciences.},
  author={Hitoshi Okamura and Masao Doi and J M Fustin and Yoshiaki Yamaguchi and Masahiro Matsuo},
  journal={Advanced drug delivery reviews},
  year={2010},
  volume={62 9-10},
  pages={876-84}
}
An internal circadian (from the Latin "circa" meaning "about" and "dien" meaning "day") clock has been found across kingdoms of life, a testimony that circadian rhythms are a basic feature of life on earth. Physiologically relevant circadian time is generated at the level of transcription-(post)translation feedback loop of clock genes, which machinery can be found in most cells throughout the body. Lesions of the hypothalamic suprachiasmatic nucleus (SCN) abolish clock oscillations in the body… CONTINUE READING

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