Mammalian centromeres: DNA sequence, protein composition, and role in cell cycle progression.

Abstract

The centromere is a specialized region of the eukaryotic chromosome that is responsible for directing chromosome movements in mitosis and for coordinating the progression of mitotic events at the crucial transition between metaphase and anaphase. In this review, we will focus on recent advances in the understanding of centromere composition at the protein and DNA level and of the role of centromeres in sister-chromatid cohesion and mitotic checkpoint control.

Statistics

0100200300'01'03'05'07'09'11'13'15'17
Citations per Year

699 Citations

Semantic Scholar estimates that this publication has 699 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Craig1999MammalianCD, title={Mammalian centromeres: DNA sequence, protein composition, and role in cell cycle progression.}, author={Jaquelyn M. Craig and William C Earnshaw and Paola Vagnarelli}, journal={Experimental cell research}, year={1999}, volume={246 2}, pages={249-62} }