Mammalian artificial chromosome formation from circular alphoid input DNA does not require telomere repeats.

@article{Ebersole2000MammalianAC,
  title={Mammalian artificial chromosome formation from circular alphoid input DNA does not require telomere repeats.},
  author={Thomas A. Ebersole and A. Ross and Elma Clark and Niolette I. McGill and Dirk Schindelhauer and Howard J. Cooke and Brenda R. Grimes},
  journal={Human molecular genetics},
  year={2000},
  volume={9 11},
  pages={1623-31}
}
Mammalian artificial chromosomes (MACs) form in HT1080 cells after transfecting linear yeast artificial chromosome constructs minimally containing competent alphoid arrays, a selectable marker and terminal human telomere repeats. Restrictions on the structure of input DNA in MAC formation were investigated by transfecting circular or linear alphoid constructs with or without human telomere arrays and by varying the position and orientation of the telomere arrays on input linear constructs… CONTINUE READING