Mammalian alkaline phosphatases are allosteric enzymes.

@article{Hoylaerts1997MammalianAP,
  title={Mammalian alkaline phosphatases are allosteric enzymes.},
  author={Marc F. Hoylaerts and Thomas Manes and Jos{\'e} Luis Mill{\'a}n},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 36},
  pages={
          22781-7
        }
}
Mammalian alkaline phosphatases (APs) are zinc-containing metalloenzymes encoded by a multigene family and functional as dimeric molecules. Using human placental AP (PLAP) as a paradigm, we have investigated whether the monomers in a given PLAP dimer are subject to cooperativity during catalysis following an allosteric model or act via a half-of-sites model, in which at any time only one single monomer is operative. Wild type and mutant PLAP homodimers and heterodimers were produced by stably… CONTINUE READING

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