Mammalian Target of Rapamycin Is a Therapeutic Target for Murine Ovarian Endometrioid Adenocarcinomas with Dysregulated Wnt/β-Catenin and PTEN

@inproceedings{Tanwar2011MammalianTO,
  title={Mammalian Target of Rapamycin Is a Therapeutic Target for Murine Ovarian Endometrioid Adenocarcinomas with Dysregulated Wnt/β-Catenin and PTEN},
  author={Pradeep S Tanwar and Lihua Zhang and Tomoko Kaneko-Tarui and Michael D. Curley and Makoto Mark Taketo and P. S. Vidya Rani and Drucilla Jane Roberts and Jose M Teixeira},
  booktitle={PloS one},
  year={2011}
}
Despite the fact that epithelial ovarian cancers are the leading cause of death from gynecological cancer, very little is known about the pathophysiology of the disease. Mutations in the WNT and PI3K pathways are frequently observed in the human ovarian endometrioid adenocarcinomas (OEAs). However, the role of WNT/β-catenin and PTEN/AKT signaling in the etiology and/or progression of this disease is currently unclear. In this report we show that mice with a gain-of-function mutation in… CONTINUE READING
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Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment.

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