Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

@article{Jacinto2004MammalianTC,
  title={Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive},
  author={Estela Jacinto and Robbie Loewith and Anja Schmidt and Shuo Lin and Markus A. R{\"u}egg and Alan Hall and Michael N. Hall},
  journal={Nature Cell Biology},
  year={2004},
  volume={6},
  pages={1122-1128}
}
The target of rapamycin (TOR) is a highly conserved protein kinase and a central controller of cell growth. In budding yeast, TOR is found in structurally and functionally distinct protein complexes: TORC1 and TORC2. A mammalian counterpart of TORC1 (mTORC1) has been described, but it is not known whether TORC2 is conserved in mammals. Here, we report that a mammalian counterpart of TORC2 (mTORC2) also exists. mTORC2 contains mTOR, mLST8 and mAVO3, but not raptor. Like yeast TORC2, mTORC2 is… Expand
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