Mammalian TBX1 Preferentially Binds and Regulates Downstream Targets Via a Tandem T-site Repeat

@inproceedings{Castellanos2014MammalianTP,
  title={Mammalian TBX1 Preferentially Binds and Regulates Downstream Targets Via a Tandem T-site Repeat},
  author={Raquel Barrio Castellanos and Qing Xie and Deyou Zheng and Ales Cvekl and Bernice E Morrow},
  booktitle={PloS one},
  year={2014}
}
Haploinsufficiency or mutation of TBX1 is largely responsible for the etiology of physical malformations in individuals with velo-cardio-facial/DiGeorge syndrome (VCFS/DGS/22q11.2 deletion syndrome). TBX1 encodes a transcription factor protein that contains an evolutionarily conserved DNA binding domain termed the T-box that is shared with other family… CONTINUE READING