Mammalian Sweet Taste Receptors

@article{Nelson2001MammalianST,
  title={Mammalian Sweet Taste Receptors},
  author={Greg Nelson and Mark A. Hoon and Jayaram Chandrashekar and Yifeng Zhang and Nicholas J. P. Ryba and Charles S. Zuker},
  journal={Cell},
  year={2001},
  volume={106},
  pages={381-390}
}
The sense of taste provides animals with valuable information about the quality and nutritional value of food. Previously, we identified a large family of mammalian taste receptors involved in bitter taste perception (the T2Rs). We now report the characterization of mammalian sweet taste receptors. First, transgenic rescue experiments prove that the Sac locus encodes T1R3, a member of the T1R family of candidate taste receptors. Second, using a heterologous expression system, we demonstrate… Expand
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It is demonstrated that T2Rs couple to gustducin in vitro, and respond to bitter tastants in a functional expression assay, implying that they function as gust Ducin-linked receptors. Expand
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The identification of a family of candidate taste receptors (the TRBs) that are members of the G-protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells are reported. Expand
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It is shown that human T1R2/T1R3 recognizes diverse natural and synthetic sweeteners, and this response is enhanced by 5′-ribonucleotides, a hallmark of umami taste, which implicate the T1Rs inUmami taste and suggest that sweet and Umami taste receptors share a common subunit. Expand
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A candidate taste receptor gene, T1r3, is described that is located at or near the mouse Sac locus, a genetic locus that controls the detection of certain sweet tastants. Expand
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TLDR
T1R3 maps near the telomere of mouse chromosome’4 rendering it a candidate for the Sac locus, a primary determinant of sweet preference in mice, and displays taste receptor cell‐specific expression. Expand
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A heterologous expression system is used to show that specific T2Rs function as bitter taste receptors, and these findings provide a plausible explanation for the uniform bitter taste that is evoked by many structurally unrelated toxic compounds. Expand
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TLDR
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The cloning and characterization of two novel seven-transmembrane domain proteins expressed in topographically distinct subpopulations of taste receptor cells and taste buds are reported and it is proposed that these genes encode taste receptors. Expand
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The results indicate that T1R3 may serve as the receptor for sweet perception in mice and was expressed in a subset of taste receptor cells in taste buds. Expand
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Electrophysiological experiments indicate that both inositol trisphosphate and cyclic nucleotides function in both bitter and sweet transduction events. Expand
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