Taste, Chemical Biology of
Evidence is accumulating to show that taste receptor and signal transduction molecules have nongustatory functions as well, and the extragustatory expression of such genes and the resulting implications are summarized in the final section.
Human Biology of Taste
- BiologyAnnals of Saudi medicine
An emerging interplay is revealed between chemical sensing in the periphery, cortical processing, performance, and physiology and likely the pathophysiology of diseases such as diabetes.
The receptors and coding logic for bitter taste
It is demonstrated, using a combination of genetic, behavioural and physiological studies, that T2R receptors are necessary and sufficient for the detection and perception of bitter compounds, and that differences in T2Rs between species can determine the selectivity of bitter taste responses.
Mammalian bitter taste perception.
- BiologyResults and problems in cell differentiation
This review summarizes current knowledge of bitter taste receptor gene expression, signal transduction, the structure-activity relationship of bitter Taste receptor proteins, as well as their variability leading to a high degree of individualization of this taste quality in mammals.
An amino-acid taste receptor
This work identifies and characterize a mammalian amino-acid taste receptor and shows that sequence differences in T1R receptors within and between species (human and mouse) can significantly influence the selectivity and specificity of taste responses.
Taste Receptor Gene Expression Outside the Gustatory System
This review summarizes current knowledge on the occurrence and functional implications of taste receptive molecules outside the oral cavity and examines the roles taste receptors fulfill in vertebrates, which are currently envisioned much broader than thought previously.
Molecular basis of bitter taste
- BiologyCell Biochemistry and Biophysics
The functional characterization of some of the receptors that these genes encode suggests that it will be possible to understand more precisely their specific functions and to address unresolved questions in bitter taste.
Molecular neurophysiology of taste in Drosophila
- BiologyCellular and Molecular Life Sciences CMLS
It is found that particular tarsal gustatory sensilla respond to bitter compounds, and determination of the molecular bases for this heterogeneity could lead to an understanding of how the sensory information is processed in the brain and how this in turn is linked to behavior.
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A family of candidate taste receptors in human and mouse
The identification of a family of candidate taste receptors (the TRBs) that are members of the G-protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells are reported.
Human receptors for sweet and umami taste
- BiologyProceedings of the National Academy of Sciences of the United States of America
It is shown that human T1R2/T1R3 recognizes diverse natural and synthetic sweeteners, and this response is enhanced by 5′-ribonucleotides, a hallmark of umami taste, which implicate the T1Rs inUmami taste and suggest that sweet and Umami taste receptors share a common subunit.
A candidate taste receptor gene near a sweet taste locus
- BiologyNature Neuroscience
A candidate taste receptor gene, T1r3, is described that is located at or near the mouse Sac locus, a genetic locus that controls the detection of certain sweet tastants.
Identification of a novel member of the T1R family of putative taste receptors
- BiologyJournal of neurochemistry
T1R3 maps near the telomere of mouse chromosome’4 rendering it a candidate for the Sac locus, a primary determinant of sweet preference in mice, and displays taste receptor cell‐specific expression.
Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac
- BiologyNature Genetics
A likely candidate is identified: T1R3, a previously unknown G protein-coupled receptor (GPCR) and the only GPCR in this region of the sequenced human genome syntenous to the region of Sac in mouse, which is the major determinant of differences between sweet-sensitive and -insensitive strains of mice in their responsiveness to saccharin, sucrose and other sweeteners.
Putative Mammalian Taste Receptors A Class of Taste-Specific GPCRs with Distinct Topographic Selectivity
Molecular genetic identification of a candidate receptor gene for sweet taste.
- BiologyBiochemical and biophysical research communications
The results indicate that T1R3 may serve as the receptor for sweet perception in mice and was expressed in a subset of taste receptor cells in taste buds.