Mammalian Ste20-like kinase 4 promotes pituitary cell proliferation and survival under hypoxia.

@article{Xiong2015MammalianSK,
  title={Mammalian Ste20-like kinase 4 promotes pituitary cell proliferation and survival under hypoxia.},
  author={Weipeng Xiong and Aaron J. Knox and Mei Q Xu and Katja Kiseljak-Vassiliades and Sean P Colgan and Kelley S Brodsky and Bette K Kleinschmidt-DeMasters and Kevin O. Lillehei and Margaret E. Wierman},
  journal={Molecular endocrinology},
  year={2015},
  volume={29 3},
  pages={460-72}
}
The genetic and molecular mechanisms that initiate and maintain pituitary tumorigenesis are poorly understood. Nonfunctioning tumors of the gonadotrope lineage represent 35% of all tumors; are usually macroadenomas, often resulting in hypopituitarism; and have no medical treatments. Using expression microarrays combined with whole-genome copy number screens on individual human tumors, we identified the mammalian sterile-20-like kinase (MST4) transcript, which was amplified within chromosome… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS