Mammalian SRP receptor switches the Sec61 translocase from Sec62 to SRP-dependent translocation

@inproceedings{Jadhav2015MammalianSR,
  title={Mammalian SRP receptor switches the Sec61 translocase from Sec62 to SRP-dependent translocation},
  author={Bhalchandra Jadhav and Michael J McKenna and Nicholas Johnson and Stephen High and Irmgard Sinning and Martin R Pool},
  booktitle={Nature communications},
  year={2015}
}
Two distinct pathways deliver secretory proteins to the Sec61 protein translocase in the endoplasmic reticulum membrane. The canonical pathway requires the signal recognition particle (SRP) and its cognate receptor (SR), and targets ribosome-associated proteins to the Sec translocase. The SRP-independent pathway requires the Sec translocase-associated ER membrane protein Sec62 and can be uncoupled from translation. Here we show that SR switches translocons to SRP-dependent translocation by… CONTINUE READING
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