Mammalian SEPT2 is required for scaffolding nonmuscle myosin II and its kinases.

@article{Joo2007MammalianSI,
  title={Mammalian SEPT2 is required for scaffolding nonmuscle myosin II and its kinases.},
  author={Emily Joo and Mark C Surka and William S. Trimble},
  journal={Developmental cell},
  year={2007},
  volume={13 5},
  pages={677-90}
}
Mammalian septin SEPT2 belongs to a conserved family of filamentous GTPases that are associated with actin stress fibers in interphase cells and the contractile ring in dividing cells. Although SEPT2 is essential for cytokinesis, its role in this process remains undefined. Here, we report that SEPT2 directly binds nonmuscle myosin II (myosin II), and this association is important for fully activating myosin II in interphase and dividing cells. Inhibition of the SEPT2-myosin II interaction in… CONTINUE READING

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